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Mitophagy is initiated by mitochondrial translocation of Pink1 with Parkin recruitment, followed by the general autophagy pathway including LC3b recruitment and lysosomal degradation. Serum-starvation can induce generalized autophagy whereas CCCP specifically induces mitophagy. This study focuses on importance of mitophagy in ARPE19 cells under acute stress Induction of mitophagy/autophagy may be a treatment strategy to prevent RPE degeneration during stress. Autophagic dysregulation have been suggested in a variety of neurodegenerative diseases including age-related macular degeneration (AMD), but mitophagy has not been studied in depth. Autophagy and mitophagy are protective mechanisms in cells, particularly Retinal Pigment epithelium (RPE), that are constantly under stress. 9/7/2023 0 Comments Skype for business web appInstead, the user is connected to both calls. 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